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Fibrinogen That Appears in Bowman's Space of Proteinuric Kidneys in vivo Activates Podocyte Toll-Like Receptors 2 and 4 in vitro

BACKGROUND: Composition of nonselective proteinuria includes several endogenous ligands of Toll-like receptors (TLRs) not normally present in Bowman's space, thus raising the possibility that TLRs are involved in proteinuria-mediated podocyte injury. METHODS: Kidneys of NEP25 mice, a model of g...

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Bibliografiske detaljer
Main Authors: Motojima, Masaru, Matsusaka, Taiji, Kon, Valentina, Ichikawa, Iekuni
Format: Artigo
Sprog:Inglês
Udgivet: S. Karger AG 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857683/
https://ncbi.nlm.nih.gov/pubmed/19887845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000254390
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