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Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding

Pyridoxal-5′-phosphate (PLP), in addition to its known metabolic functions, inactivates many DNA-dependent enzymes through conjugation to their critical amino groups. We have investigated the ability of PLP to inhibit bifunctional DNA repair glycosylases, which possess a catalytic amine. Of six enzy...

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Bibliografiske detaljer
Main Authors: Grin, Inga R., Rieger, Robert A., Zharkov, Dmitry O.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857644/
https://ncbi.nlm.nih.gov/pubmed/20175991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.02.121
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