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Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding
Pyridoxal-5′-phosphate (PLP), in addition to its known metabolic functions, inactivates many DNA-dependent enzymes through conjugation to their critical amino groups. We have investigated the ability of PLP to inhibit bifunctional DNA repair glycosylases, which possess a catalytic amine. Of six enzy...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857644/ https://ncbi.nlm.nih.gov/pubmed/20175991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.02.121 |
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