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Melanocortins Mimic the Effects of Leptin to Restore Reproductive Function in Lean Hypogonadotropic Ewes

BACKGROUND/AIMS: Leptin restores gonadotropic function in lean hypogonadotropic animals by an unknown mechanism. We aimed to test the hypothesis that restoration of gonadotropic function is a result of an upregulation of central acetylated melanocortin production. METHODS AND RESULTS: Lean ovariecto...

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Autori principali: Backholer, Kathryn, Bowden, Marissa, Gamber, Kevin, Bjørbæk, Christian, Iqbal, Javed, Clarke, Iain J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: S. Karger AG 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857620/
https://ncbi.nlm.nih.gov/pubmed/19923792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000260060
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