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Ultrafast Dynamics Show That the Theophylline and 3-Methylxanthine Aptamers Employ a Conformational Capture Mechanism for Binding Their Ligands

RNAs often exhibit a high degree of conformational dynamics and heterogeneity, leading to a rugged energy landscape. However, the roles of conformational heterogeneity and rapid dynamics in molecular recognition or RNA function have not been extensively elucidated. Ultrafast time-resolved fluorescen...

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מידע ביבליוגרפי
Main Authors: Lee, Sang Won, Zhao, Liang, Pardi, Arthur, Xia, Tianbing
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857344/
https://ncbi.nlm.nih.gov/pubmed/20214401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100106c
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