Eculizumab prevents intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria and unmasks low-level extravascular hemolysis occurring through C3 opsonization

BACKGROUND: Paroxysmal nocturnal hemoglobinuria is an acquired hemolytic anemia characterized by intravascular hemolysis which has been demonstrated to be effectively controlled with eculizumab. However, lactate dehydrogenase levels remain slightly elevated and haptoglobin levels remain low in some...

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Autori principali: Hill, Anita, Rother, Russell P., Arnold, Louise, Kelly, Richard, Cullen, Matthew J., Richards, Stephen J., Hillmen, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2010
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857185/
https://ncbi.nlm.nih.gov/pubmed/20145265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.007229
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