Eculizumab prevents intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria and unmasks low-level extravascular hemolysis occurring through C3 opsonization

BACKGROUND: Paroxysmal nocturnal hemoglobinuria is an acquired hemolytic anemia characterized by intravascular hemolysis which has been demonstrated to be effectively controlled with eculizumab. However, lactate dehydrogenase levels remain slightly elevated and haptoglobin levels remain low in some...

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Bibliographic Details
Main Authors: Hill, Anita, Rother, Russell P., Arnold, Louise, Kelly, Richard, Cullen, Matthew J., Richards, Stephen J., Hillmen, Peter
Format: Artigo
Language:Inglês
Published: Ferrata Storti Foundation 2010
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857185/
https://ncbi.nlm.nih.gov/pubmed/20145265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.007229
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