Impaired Glucose Tolerance and Predisposition to the Fasted State in Liver Glycogen Synthase Knock-out Mice

Conversion to glycogen is a major fate of ingested glucose in the body. A rate-limiting enzyme in the synthesis of glycogen is glycogen synthase encoded by two genes, GYS1, expressed in muscle and other tissues, and GYS2, primarily expressed in liver (liver glycogen synthase). Defects in GYS2 cause...

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Autores principales: Irimia, Jose M., Meyer, Catalina M., Peper, Caron L., Zhai, Lanmin, Bock, Cheryl B., Previs, Stephen F., McGuinness, Owen P., DePaoli-Roach, Anna, Roach, Peter J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857087/
https://ncbi.nlm.nih.gov/pubmed/20178984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.106534
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