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Celastrol, a Triterpene, Enhances TRAIL-induced Apoptosis through the Down-regulation of Cell Survival Proteins and Up-regulation of Death Receptors

Whether celastrol, a triterpene from traditional Chinese medicine, can modulate the anticancer effects of TRAIL, the cytokine that is currently in clinical trial, was investigated. As indicated by assays that measure plasma membrane integrity, phosphatidylserine exposure, mitochondrial activity, and...

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Detalhes bibliográficos
Main Authors: Sung, Bokyung, Park, Byoungduck, Yadav, Vivek R., Aggarwal, Bharat B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857028/
https://ncbi.nlm.nih.gov/pubmed/20154087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090209
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