Communication between Thiamin Cofactors in the Escherichia coli Pyruvate Dehydrogenase Complex E1 Component Active Centers: EVIDENCE FOR A “DIRECT PATHWAY” BETWEEN THE 4′-AMINOPYRIMIDINE N1′ ATOMS

Kinetic, spectroscopic, and structural analysis tested the hypothesis that a chain of residues connecting the 4′-aminopyrimidine N1′ atoms of thiamin diphosphates (ThDPs) in the two active centers of the Escherichia coli pyruvate dehydrogenase complex E1 component provides a signal transduction path...

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Bibliographische Detailangaben
Hauptverfasser: Nemeria, Natalia S., Arjunan, Palaniappa, Chandrasekhar, Krishnamoorthy, Mossad, Madouna, Tittmann, Kai, Furey, William, Jordan, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856997/
https://ncbi.nlm.nih.gov/pubmed/20106967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.069179
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