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Activation of cyclin B1–Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis

The cyclin B–Cdk1 kinase triggers mitosis in most eukaryotes. In animal cells, cyclin B shuttles between the nucleus and cytoplasm in interphase before rapidly accumulating in the nucleus at prophase, which promotes disassembly of the nuclear lamina and nuclear envelope breakdown (NEBD). What trigge...

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Bibliografiske detaljer
Main Authors: Gavet, Olivier, Pines, Jonathon
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856909/
https://ncbi.nlm.nih.gov/pubmed/20404109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200909144
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