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The N-Terminal Domain of Nogo-A Inhibits Cell Adhesion and Axonal Outgrowth by an Integrin-Specific Mechanism

Myelin-derived Nogo-A protein limits axonal growth after CNS injury. One domain binds to the Nogo-66 receptor to inhibit axonal outgrowth, whereas a second domain, Amino-Nogo, inhibits axonal outgrowth and cell adhesion through unknown mechanisms. Here, we show that Amino-Nogo inhibition depends str...

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Bibliographic Details
Main Authors: Hu, Fenghua, Strittmatter, Stephen M.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856844/
https://ncbi.nlm.nih.gov/pubmed/18234903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1068-07.2008
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