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pH-dependent self-association of zinc-free Insulin characterized by concentration-gradient static light scattering

Insulin self-association at pH 1.85, 1.95, 3.0, 7.2, 8.0 and 10 was studied via composition gradient light scattering (CG-SLS). At pH 1.95 in acetic acid, insulin was found to exist as a monomer, and in pH 1.85 HCl as a dimer. At pH values of 3.0 – 8.0, the dependence of scattering intensity upon to...

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Detalhes bibliográficos
Main Authors: Attri, Arun K., Fernández, Cristina, Minton, Allen P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856799/
https://ncbi.nlm.nih.gov/pubmed/20202737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2010.02.002
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