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Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): Profound asymmetry in the crystal structure of the ‘open’ state

In all organisms adenylate kinases (Adks) play a vital role in cellular energy metabolism and nucleic acid synthesis. Due to differences in catalytic properties between the Adks found in prokaryotes and in the cytoplasm of eukaryotes, there is interest in targeting this enzyme for new drugs therapie...

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Autors principals: Buchko, Garry W., Robinson, Howard, Abendroth, Jan, Staker, Bart L., Myler, Peter J.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856777/
https://ncbi.nlm.nih.gov/pubmed/20331978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.03.112
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