Selective Estrogen Receptor Down-Regulator and Selective Estrogen Receptor Modulators Differentially Regulate Lactotroph Proliferation

BACKGROUND: We recently reported that estrogen receptor α (ERα), even in absence of estrogen (E2), plays a critical role in lactotroph homeostasis. The anti-estrogen ICI 182780 (ICI), but not tamoxifen or raloxifene, rapidly promoted the degradation of ERα, and inhibited cell proliferation. However,...

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Detaylı Bibliyografya
Asıl Yazarlar: Kansra, Sanjay, Chen, Shenglin, Bangaru, Madhavi Latha Yadav, Sneade, Leighton, Dunckley, Joseph A., Ben-Jonathan, Nira
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856675/
https://ncbi.nlm.nih.gov/pubmed/20419096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010060
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