Histone Deacetylase Inhibitor Valproic Acid Inhibits Cancer Cell Proliferation via Down-regulation of the Alzheimer Amyloid Precursor Protein

The β-amyloid precursor protein (APP) represents a type I transmembrane glycoprotein that is ubiquitously expressed. In the brain, it is a key player in the molecular pathogenesis of Alzheimer disease. Its physiological function is however less well understood. Previous studies showed that APP is up...

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Bibliografische gegevens
Hoofdauteurs: Venkataramani, Vivek, Rossner, Christian, Iffland, Lara, Schweyer, Stefan, Tamboli, Irfan Y., Walter, Jochen, Wirths, Oliver, Bayer, Thomas A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2010
Onderwerpen:
Molecular Bases of Disease
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856276/
https://ncbi.nlm.nih.gov/pubmed/20145244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057836
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