Selective Translocation of the Bordetella pertussis Adenylate Cyclase Toxin across the Basolateral Membranes of Polarized Epithelial Cells

The catalytic domain of Bordetella pertussis adenylate cyclase toxin (ACT) translocates directly across the plasma membrane of mammalian cells to induce toxicity by the production of cAMP. Here, we use electrophysiology to examine the translocation of toxin into polarized epithelial cells that model...

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Autors principals: Eby, Joshua C., Ciesla, William P., Hamman, Wendy, Donato, Gina M., Pickles, Raymond J., Hewlett, Erik L., Lencer, Wayne I.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856274/
https://ncbi.nlm.nih.gov/pubmed/20139088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.089219
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