Molecular Mechanisms of How Mercury Inhibits Water Permeation through Aquaporin-1: Understanding by Molecular Dynamics Simulation

Aquaporin (AQP) functions as a water-conducting pore. Mercury inhibits the water permeation through AQP. Although site-directed mutagenesis has shown that mercury binds to Cys(189) during the inhibition process, it is not fully understood how this inhibits the water permeation through AQP1. We carri...

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Bibliografiska uppgifter
Huvudupphovsmän: Hirano, Yoshinori, Okimoto, Noriaki, Kadohira, Ikuko, Suematsu, Makoto, Yasuoka, Kenji, Yasui, Masato
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Biophysical Society 2010
Ämnen:
Channels and Transporters
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856166/
https://ncbi.nlm.nih.gov/pubmed/20409470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.12.4310
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