Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer

AIM: Docetaxel has a low oral bioavailability due to affinity for P-glycoprotein and cytochrome P450 (CYP) 3A4 enzymes. Inhibition of the CYP3A4 enzymes by ritonavir resulted in increased oral bioavailability. The aim of this study was to develop a population pharmacokinetic (PK) model and to evalua...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Koolen, Stijn L W, Oostendorp, Roos L, Beijnen, Jos H, Schellens, Jan H M, Huitema, Alwin D R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2010
Schlagworte:
Pharmacokinetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856047/
https://ncbi.nlm.nih.gov/pubmed/20573082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03621.x
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