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New molecular targets in radiotherapy: DNA damage signalling and repair in targeted and non-targeted cells

Ionising radiation plays a key role in therapy due to its ability to directly induce DNA damage, in particular DNA double-strand breaks leading to cell death. Cells have multiple repair pathways which attempt to maintain genomic stability. DNA repair proteins have become key targets for therapy, usi...

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Hlavní autoři: Burdak-Rothkamm, Susanne, Prise, Kevin M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855957/
https://ncbi.nlm.nih.gov/pubmed/19835868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2009.09.068
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