Variation in anastrozole metabolism and pharmacodynamics in women with early breast cancer

Aromatase inhibitors (AIs) play a prominent role in the management of postmenopausal women with endocrine sensitive breast cancer, but there is large variability in both efficacy and tolerability. The purpose of our study was to define inter-individual variation in anastrozole metabolism and pharmac...

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Autori principali: Ingle, James N., Buzdar, Aman U., Schaid, Daniel J., Goetz, Matthew P., Batzler, Anthony, Robson, Mark E., Northfelt, Donald W., Olson, Janet E., Perez, Edith A., Desta, Zeruesenay, Weintraub, Randy A., Williard, Clark V., Flockhart, David A., Weinshilboum, Richard M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855746/
https://ncbi.nlm.nih.gov/pubmed/20354183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3024
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