Protection of epithelial barrier function by the Crohn’s disease associated gene, protein tyrosine phosphatase N2

BACKGROUND & AIMS: Protein tyrosine phosphatase N2 (PTPN2) has been identified as a Crohn’s disease (CD) candidate gene. However, a role for PTPN2 in the pathogenesis of CD has not been identified. Increased permeability of the intestinal epithelium is believed to contribute prominently to CD. T...

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Detalhes bibliográficos
Main Authors: Scharl, Michael, Paul, Gisela, Weber, Achim, Jung, Barbara C., Docherty, Michael J., Hausmann, Martin, Rogler, Gerhard, Barrett, Kim E., McCole, Declan F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855721/
https://ncbi.nlm.nih.gov/pubmed/19818778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.07.078
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