Temperature Triggered Self-Assembly of Polypeptides into Multivalent Spherical Micelles

We report herein thermally responsive elastin-like polypeptides (ELPs) in a linear AB diblock architecture with an N-terminal peptide ligand that self-assemble into spherical micelles when heated slightly above body temperature. A series of 10 ELP block copolymers (ELP(BC)s) with different molecular...

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Main Authors: Dreher, Matthew R., Simnick, Andrew J., Fischer, Karl, Smith, Richard J., Patel, Anand, Schmidt, Manfred, Chilkoti, Ashutosh
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855373/
https://ncbi.nlm.nih.gov/pubmed/18085778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0764862
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