Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

Inflammatory signaling plays a key role in tumor progression, and the pleiotropic cytokine interleukin-6 (IL-6) is an important mediator of protumorigenic properties. Activation of the aryl hydrocarbon receptor (AHR) with exogenous ligands coupled with inflammatory signals can lead to synergistic in...

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Bibliographic Details
Main Authors: DiNatale, Brett C., Murray, Iain A., Schroeder, Jennifer C., Flaveny, Colin A., Lahoti, Tejas S., Laurenzana, Elizabeth M., Omiecinski, Curtis J., Perdew, Gary H.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Molecular Toxicology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855350/
https://ncbi.nlm.nih.gov/pubmed/20106948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq024
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