Long-term AZT Exposure Alters the Metabolic Capacity of Cultured Human Lymphoblastoid Cells

The antiretroviral efficacy of 3′-azido-3′-deoxythymidine (AZT) is dependent upon intracellular mono-, di-, and triphosphorylation and incorporation into DNA in place of thymidine. Thymidine kinase 1 (TK-1) catalyzes the first step of this pathway. MOLT-3, human lymphoblastoid cells, were exposed to...

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Main Authors: Olivero, Ofelia A., Vazquez, Irma L., Cooch, Catherine C., Ming, Jessica, Keller, Emily, Yu, Mia, Borojerdi, Jennifer P., Braun, Hannan M., McKee, Edward, Poirier, Miriam C.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
Teme:
Molecular Toxicology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855349/
https://ncbi.nlm.nih.gov/pubmed/20106944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq023
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