The RING-CH Ligase K5 Antagonizes Restriction of KSHV and HIV-1 Particle Release by Mediating Ubiquitin-Dependent Endosomal Degradation of Tetherin

Tetherin (CD317/BST2) is an interferon-induced membrane protein that inhibits the release of diverse enveloped viral particles. Several mammalian viruses have evolved countermeasures that inactivate tetherin, with the prototype being the HIV-1 Vpu protein. Here we show that the human herpesvirus Kap...

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Main Authors: Pardieu, Claire, Vigan, Raphaël, Wilson, Sam J., Calvi, Alessandra, Zang, Trinity, Bieniasz, Paul, Kellam, Paul, Towers, Greg J., Neil, Stuart J. D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855335/
https://ncbi.nlm.nih.gov/pubmed/20419159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000843
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