Gene Therapy for Bladder Overactivity and Nociception with Herpes Simplex Virus Vectors Expressing Preproenkephalin

Interstitial cystitis/painful bladder syndrome (IC/PBS) is a major challenge to treat. We studied the effect of targeted and localized expression of enkephalin in afferent nerves that innervate the bladder by gene transfer using replication-defective herpes simplex virus (HSV) vectors in a rat model...

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Detalhes bibliográficos
Main Authors: Yokoyama, Hitoshi, Sasaki, Katsumi, Franks, Michael E., Goins, William F., Goss, James R., de Groat, William C., Glorioso, Joseph C., Chancellor, Michael B., Yoshimura, Naoki
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2009
Assuntos:
Scientific Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855255/
https://ncbi.nlm.nih.gov/pubmed/20377371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2008.094
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