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Pharmacology of Proton Pump Inhibitors

The gastric H,K-ATPase is the primary target for the treatment of acid-related diseases. Proton pump inhibitors (PPIs) are weak bases composed of two moieties, a substituted pyridine with a primary pK(a) of about 4.0, which allows selective accumulation in the secretory canaliculus of the parietal c...

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Detalhes bibliográficos
Main Authors: Shin, Jai Moo, Sachs, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855237/
https://ncbi.nlm.nih.gov/pubmed/19006606
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