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Pharmacokinetics and Pharmacodynamics of the Proton Pump Inhibitors
Proton pump inhibitor (PPI) is a prodrug which is activated by acid. Activated PPI binds covalently to the gastric H(+), K(+)-ATPase via disulfide bond. Cys813 is the primary site responsible for the inhibition of acid pump enzyme, where PPIs bind. Omeprazole was the first PPI introduced in market,...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Korean Society of Neurogastroenterology and Motility
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3548122/ https://ncbi.nlm.nih.gov/pubmed/23350044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5056/jnm.2013.19.1.25 |
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