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The Effects of Matrix Stiffness and RhoA on the Phenotypic Plasticity of Smooth Muscle Cells in a 3-D Biosynthetic Hydrogel System

Studies using 2-D cultures have shown that the mechanical properties of the extracellular matrix (ECM) influence cell migration, spreading, proliferation, and differentiation; however, cellular mechanosensing in 3-D remains under-explored. To investigate this topic, a unique biomaterial system based...

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Autors principals: Peyton, Shelly R., Kim, Peter D., Ghajar, Cyrus M., Seliktar, Dror, Putnam, Andrew J.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855209/
https://ncbi.nlm.nih.gov/pubmed/18342366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2008.02.005
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