Plasma Insulin-like Growth Factors, Insulin-like Binding Protein-3, and Outcome in Metastatic Colorectal Cancer: Results from Intergroup Trial N9741

PURPOSE: Insulin-like growth factor (IGF)-I and IGF-II stimulate neoplastic cell growth and inhibit apoptosis, whereas IGF-binding protein-3 (IGFBP-3) inhibits the bioavailability of IGF-I and has independent proapoptotic activity. We examined the influence of baseline plasma levels of IGF-I, IGF-II...

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Autori principali: Fuchs, Charles S., Goldberg, Richard M., Sargent, Daniel J., Meyerhardt, Jeffrey A., Wolpin, Brian M., Green, Erin M., Pitot, Henry C., Pollak, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855207/
https://ncbi.nlm.nih.gov/pubmed/19073970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0480
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