Variability in drug metabolizing enzyme activity in HIV-infected patients

AIMS: To evaluate variability in cytochrome P450 (CYP) 1A2, CYP2D6, CYP3A, N-acetyltransferase 2 (NAT2), and xanthine oxidase (XO) activity in HIV-infected patients and compare this with data from uninfected, healthy volunteers. METHODS: Ten HIV-infected men and seven women on medication affecting C...

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Main Authors: Jones, Amanda E., Brown, Kevin C., Werner, Rebecca E., Gotzkowsky, Karl, Gaedigk, Andrea, Blake, Mike, Hein, David W., van der Horst, Charles, Kashuba, Angela D. M.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855129/
https://ncbi.nlm.nih.gov/pubmed/20084375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-009-0777-6
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