Nitric Oxide Prodrug JS-K Inhibits Ubiquitin E1 and Kills Tumor Cells Retaining Wild Type p53

Eitemau Tebyg

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• Mechanism of action for the cytotoxic effects of the nitric oxide prodrug JS-K in murine erythroleukemia cells
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• Stabilization of the Nitric Oxide (NO) Prodrugs and Anti-Cancer Leads, PABA/NO and Double JS-K through Incorporation into PEG-Protected Nanoparticles
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• JS-K, a nitric oxide-releasing prodrug, induces breast cancer cell death while sparing normal mammary epithelial cells
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