TIMP-2 mediates the anti-invasive effects of the nitric oxide-releasing prodrug JS-K in breast cancer cells

INTRODUCTION: Tumor invasion and metastasis remain a major cause of mortality in breast cancer patients. High concentrations of nitric oxide (NO) suppress tumor invasion and metastasis in vivo. NO prodrugs generate large amounts of NO upon metabolism by appropriate intracellular enzymes, and therefo...

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Main Authors: Simeone, Ann-Marie, McMurtry, Vanity, Nieves-Alicea, René, Saavedra, Joseph E, Keefer, Larry K, Johnson, Marcella M, Tari, Ana M
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481491/
https://ncbi.nlm.nih.gov/pubmed/18474097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2095
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