Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains

The mechanisms underlying Golgi targeting and vesiculation are unknown, although the responsible phosphatidylinositol 4-phosphate (PtdIns(4)P) ligand and four-phosphate-adaptor protein (FAPP) modules have been defined. The micelle-bound structure of the FAPP1 pleckstrin homology domain reveals how i...

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Main Authors: Lenoir, Marc, Coskun, Ünal, Grzybek, Michal, Cao, Xinwang, Buschhorn, Sabine B, James, Jonathan, Simons, Kai, Overduin, Michael
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2010
Assuntos:
Scientific Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854595/
https://ncbi.nlm.nih.gov/pubmed/20300118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.28
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