The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice

RATIONALE: Many of the biochemical, physiological, and behavioral effects of ethanol are known to be mediated by ionotropic glutamate receptors. Emerging evidence implicates metabotropic glutamate receptors (mGluRs) in the biobehavioral effects of ethanol and other drugs of abuse, but there is littl...

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Main Authors: Hodge, Clyde W., Miles, Michael F., Sharko, Amanda C., Stevenson, Rebekah A., Hillmann, Jennie R., Lepoutre, Veronique, Besheer, Joyce, Schroeder, Jason P.
Format: Artigo
Sprog:Inglês
Udgivet: 2005
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854492/
https://ncbi.nlm.nih.gov/pubmed/16292590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-005-0217-y
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