CUE-INDUCED REINSTATEMENT OF ALCOHOL-SEEKING BEHAVIOR IS ASSOCIATED WITH INCREASED ERK(1/2) PHOSPHORYLATION IN SPECIFIC LIMBIC BRAIN REGIONS: BLOCKADE BY THE MGLUR5 ANTAGONIST MPEP

Relapse to alcohol use after periods of abstinence is a hallmark behavioral pathology of alcoholism and a major clinical problem. Emerging evidence indicates that metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate relapse to alcohol-seeking behavior but the molecular mechanisms of this...

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Bibliographic Details
Main Authors: Schroeder, Jason P., Spanos, Marina, Stevenson, Jennie R., Besheer, Joyce, Salling, Michael, Hodge, Clyde W.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613007/
https://ncbi.nlm.nih.gov/pubmed/18619984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2008.06.057
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