Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells

The activating mutation JAK2 V617F plays a central role in the pathogenesis of polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Inhibition of JAK2 activity leads to growth inhibition and apoptosis in cells with mutated JAK2. However, the proapoptotic proteins involved in JAK2...

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Bibliografiske detaljer
Main Authors: Will, Britta, Siddiqi, Tanya, Jordà, Meritxell Alberich, Shimamura, Takeshi, Luptakova, Katarina, Staber, Philipp B., Costa, Daniel B., Steidl, Ulrich, Tenen, Daniel G., Kobayashi, Susumu
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2010
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854433/
https://ncbi.nlm.nih.gov/pubmed/20160166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-209544
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