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Ganaxolone Suppression of Behavioral and Electrographic Seizures in the Mouse Amygdala Kindling Model
Ganaxolone (3α-hydroxy-3β-methyl-5α-pregnan-20-one), a synthetic analog of the endogenous neurosteroid allopregnanolone and a positive allosteric modulator of GABA(A) receptors, may represent a new treatment approach for epilepsy. Here we demonstrate that pretreatment with ganaxolone (1.25–20 mg/kg,...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2854307/ https://ncbi.nlm.nih.gov/pubmed/20172694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eplepsyres.2010.01.009 |
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