CARDIOMYOPATHY-CAUSING DELETION K210 IN CARDIAC TROPONIN T ALTERS PHOSPHORYLATION PROPENSITY OF SARCOMERIC PROTEINS

Ca(2+) desensitization of myofilaments is indicated as a primary mechanism for the pathogenesis of familial dilated cardiomyopathy (DCM) associated with the deletion of lysine 210 (ΔK210) in cardiac troponin T (cTnT). ΔK210 knock-in mice closely recapitulate the clinical phenotypes documented in pat...

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Main Authors: Duke, Liliana S., Garcia-Cazarin, Mary L., Sumandea, C. Amelia, Sievert, Gail A., Balke, C. William, Zhan, Dong-Yun, Morimoto, Sachio, Sumandea, Marius P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854196/
https://ncbi.nlm.nih.gov/pubmed/20079745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.01.005
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