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CARDIOMYOPATHY-CAUSING DELETION K210 IN CARDIAC TROPONIN T ALTERS PHOSPHORYLATION PROPENSITY OF SARCOMERIC PROTEINS
Ca(2+) desensitization of myofilaments is indicated as a primary mechanism for the pathogenesis of familial dilated cardiomyopathy (DCM) associated with the deletion of lysine 210 (ΔK210) in cardiac troponin T (cTnT). ΔK210 knock-in mice closely recapitulate the clinical phenotypes documented in pat...
में बचाया:
| मुख्य लेखकों: | , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2010
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2854196/ https://ncbi.nlm.nih.gov/pubmed/20079745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.01.005 |
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