Drosophila VHL tumor-suppressor gene regulates epithelial morphogenesis by promoting microtubule and aPKC stability

Mutations in the human von Hippel-Lindau (VHL) genes are the cause of VHL disease, which displays multiple benign and malignant tumors. The VHL gene has been shown to regulate angiogenic potential and glycolic metabolism via its E3 ubiquitin ligase function against the alpha subunit of hypoxia-induc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Duchi, Serena, Fagnocchi, Luca, Cavaliere, Valeria, Hsouna, Anita, Gargiulo, Giuseppe, Hsu, Tien
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Company of Biologists 2010
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853850/
https://ncbi.nlm.nih.gov/pubmed/20388653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.042804
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