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Spinal Muscular Atrophy: Why do low levels of SMN make motor neurons sick?

Many neurogenetic disorders are caused by the mutation of ubiquitously expressed genes. Spinal muscular atrophy is one such disorder and is caused by loss or mutation of the survival motor neuron 1 gene (SMN1), leading to reduced SMN protein levels and a selective dysfunction of motor neurons. SMN,...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Burghes, Arthur H.M., Beattie, Christine E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853768/
https://ncbi.nlm.nih.gov/pubmed/19584893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrn2670
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