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Spinal Muscular Atrophy: Why do low levels of SMN make motor neurons sick?
Many neurogenetic disorders are caused by the mutation of ubiquitously expressed genes. Spinal muscular atrophy is one such disorder and is caused by loss or mutation of the survival motor neuron 1 gene (SMN1), leading to reduced SMN protein levels and a selective dysfunction of motor neurons. SMN,...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2853768/ https://ncbi.nlm.nih.gov/pubmed/19584893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrn2670 |
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