Cell-Extrinsic Defective Lymphocyte Development in Lmna(-/-) Mice

BACKGROUND: Mutations in the LMNA gene, which encodes all A-type lamins, result in a variety of human diseases termed laminopathies. Lmna(-/-) mice appear normal at birth but become runted as early as 2 weeks of age and develop multiple tissue defects that mimic some aspects of human laminopathies....

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Bibliographic Details
Main Authors: Hale, J. Scott, Frock, Richard L., Mamman, Sara A., Fink, Pamela J., Kennedy, Brian K.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853576/
https://ncbi.nlm.nih.gov/pubmed/20405040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010127
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