Nuclear Receptor CAR Represses TNFα-Induced Cell Death by Interacting with the Anti-Apoptotic GADD45B

BACKGROUND: Phenobarbital (PB) is the most well-known among numerous non-genotoxic carcinogens that cause the development of hepatocellular carcinoma (HCC). PB activates nuclear xenobiotic receptor Constitutive Active/Androstane Receptor (CAR; NR1I3) and this activation is shown to determine PB prom...

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Detalhes bibliográficos
Main Authors: Yamamoto, Yukio, Moore, Rick, Flavell, Richard A., Lu, Binfeng, Negishi, Masahiko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853562/
https://ncbi.nlm.nih.gov/pubmed/20404936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010121
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