Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia

To investigate the impact of mipomersen, an apolipoprotein B-100 (apoB) synthesis inhibitor, on intra-hepatic triglyceride content (IHTG content), we conducted a randomized, double-blind, placebo-controlled study in 21 patients with familial hypercholesterolemia (FH). Subjects received a weekly subc...

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Autores principales: Visser, Maartje E., Akdim, Fatima, Tribble, Diane L., Nederveen, Aart J., Kwoh, T. Jesse, Kastelein, John J. P., Trip, Mieke D., Stroes, Erik S. G.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2010
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853432/
https://ncbi.nlm.nih.gov/pubmed/20008831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M002915
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