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Rho Kinase Inhibition Rescues the Endothelial Cell Cerebral Cavernous Malformation Phenotype
Cerebral cavernous malformations (CCM) are vascular lesions causing seizures and stroke. Mutations causing inactivation of one of three genes, ccm1, -2, or -3, are sufficient to induce vascular endothelial cell defects resulting in CCM. Herein, we show that loss of expression of the CCM1, -2, or -3...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2852911/ https://ncbi.nlm.nih.gov/pubmed/20181950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C109.097220 |
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