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Proton Affinity of the Oxyanion Hole in the Active Site of Ketosteroid Isomerase

The absorption spectra of a series of inhibitors bound at the active site of Δ(5)-3-ketosteroid isomerase from Pseudomonas putida were found to exhibit substantial variations in the contributions of the protonated and deprotonated forms. Systematic variation of the inhibitor solution pK(a) combined...

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Autors principals: Childs, William, Boxer, Steven G.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852583/
https://ncbi.nlm.nih.gov/pubmed/20143849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100074s
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