Transgenic Overexpression of Gremlin Results in Developmental Defects in Enamel and Dentin in Mice

Bone morphogenetic proteins (BMPs) and BMP antagonists play a crucial role in the regulation of tooth development. One of the BMP extracellular antagonists, gremlin, is a highly conserved 20.7-kDa glycoprotein. Previously, researchers reported that transgenic mice overexpressing gremlin under the co...

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Main Authors: Nagatomo, Kanako J., Tompkins, Kevin A., Fong, Hanson, Zhang, Hai, Foster, Brian L., Chu, Emily Y., Murakami, Ayu, Stadmeyer, Lisa, Canalis, Ernesto, Somerman, Martha J.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852574/
https://ncbi.nlm.nih.gov/pubmed/19085239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/03008200802325060
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